tren hexahydrobenzylcarbonate

Among the most common side effects associated with taking formoterol are described such typical for beta2-agonists, such as: hypokalaemia, headache, tremor, palpitations, cough, muscle cramps, lengthening the tren hexahydrobenzylcarbonate. Side effects that are typical of beclomethasone dipropionate: candidiasis of the mucous membranes of the mouth and throat, throat irritation.
As with other inhaled medications, Foster may cause paradoxical bronchospasm.
Other side effects that are typical of formoterol: platelet-topeniya, angioneurotic edema, hyperglycemia, increased the blood levels of insulin, free fatty acids, glycerol and ketone derivatives, sleep disturbances, hallucinations, fatigue, anxiety, change in taste (dysgeusia), tachycardia, tachyarrhythmia, ventricular arrythmia, angina pectoris (ischemic heart disease), atrial fibrillation, hypertension, hypotension, worsening of asthma, shortness of breath, nausea, itching, skin rash, urticaria, rash, myalgia, nephritis, peripheral edema.
Systemic effects of corticosteroids (including beclomethasone dipropionate) occur at high doses for a long time. These include: inhibition of adrenal function, decreased bone mineral density, growth retardation in children and adolescents, cataract and glaucoma. Hypersensitivity reactions include itching, rash, erythema and edema of the eyes, face, lips and throat.

Overdose
In case of overdose appear typical for tren hexahydrobenzylcarbonate symptoms associated with formoterol, such as nausea, vomiting, headache, tremor, drowsiness, palpitations, tachycardia, ventricular arrhythmias, prolongation of the QTc-interval, metabolic acidosis, hypokalemia, hyperglycemia.
If you have symptoms overdose shown symptomatic treatment. In severe cases, hospitalization. It may be considered the use of cardioselective beta-blockers in compliance with caution, since the use of these funds can cause bronchospasm. It is necessary to monitoring the level of potassium in the blood plasma.
Inhalation doses of beclomethasone dipropionate recommended above can cause temporary suppression of adrenocortical function. It does not usually require the adoption of any emergency measures, since in most cases normal adrenal function is recovered in a few days. . It is recommended to control the level of cortisol in the blood plasma
in chronic receiving excessive doses of beclomethasone dipropionate may manifest its systemic effect: it may be a significant inhibition of adrenal cortex up to adrenal crisis. Acute adrenal crisis manifested hypoglycemia accompanied by confusion and / or convulsions. Situations that can serve as a triggering factor of acute adrenal crisis, include trauma, surgery, infection or rapid dose reduction is part of the Foster beclomethasone. In chronic overdose recommended control reserve of adrenocortical function.

Interaction with other drugs
blockers β-adrenergic receptors may attenuate the effect of formoterol. Foster should not be administered simultaneously with tren hexahydrobenzylcarbonate (including eye drops) unless required cases.
In a joint reception Foster and other β-adrenergic drugs may increase formoterol side effects.
Co-administration of Foster and quinidine, disopyramide, procainamide, phenothiazines, antihistamines medicines (terfenadine), monoamine oxidase inhibitors  and tricyclic antidepressants can prolong the QTc – interval and increase the risk of ventricular arrhythmias.
in addition, levodopa, levothyroxine, oxytocin and alcohol can reduce the tolerance of the heart muscle to  agonists.
Co-administration of inhibitors, and drugs with similar properties such as furazolidone and procarbazine, may cause increased blood pressure. There is an increased risk of arrhythmias in patients receiving general anesthesia, halogenated hydrocarbons drugs.
As a result, the use  may occur hypokalemia, which may be exacerbated by the concomitant treatment of xanthine derivatives, mineral derivatives of corticosteroids or diuretics. Hypokalemia may enhance susceptibility to the development of arrhythmias in patients receiving cardiac glycosides.
Due to the content of a small amount of ethanol may be a manifestation of interaction in patients with hypersensitivity taking disulfiram or metronidazole.

Cautions
If patients have these co-morbidities, as coronary heart disease, myocardial infarction, exacerbation of hypertension, cardiac arrhythmias, congestive heart failure, diabetes, prostatic hypertrophy, glaucoma, you must take extra care when choosing .
It precautions in the treatment of patients with prolonged . Acceptance of formoterol may cause lengthening of tren hexahydrobenzylcarbonate Foster can only be used in patients with tachyarrhythmia, subject to special precautions, such as  monitoring.
It should take special precautions in patients with unstable asthma patients treated with bronchodilators short action for relief of attacks during exacerbation of severe asthma, because the risk of hypokalemia increases against the background of hypoxia and in other conditions when the increased probability of developing gipokaliemicheskogo effect. In such cases it is advisable to control the content of potassium in serum.
Inhaled formoterol high tren hexahydrobenzylcarbonate doses can lead to an increase in blood sugar levels. The treatment should monitor the concentration of blood glucose in patients with diabetes.

tren acetate half life

Foster is not intended for the initial treatment of bronchial asthma. Titration of drugs included in the Foster occurs individually and depending on the severity of the disease. This should be considered not only at the start of combination therapies but also changing in the maintenance doses if the patient requires a separate combination of different doses of active components than in Foster, to assign β2- agonists and / or glucocorticoids in separate inhalers. For adults and adolescents over 12 years: 1-2 inhalations twice daily. Patients should be under constant medical supervision for an adequate selection of the dose of Foster. The dose should be reduced to the lowest against which retained optimal control of asthma symptoms. Upon reaching full control tren acetate half life of asthma symptoms on a background of the minimum recommended dose, the next step may be to try the appointment of monotherapy with inhaled corticosteroids. No need for special dose selection for elderly patients drug. No data on the admission Foster patients with renal or hepatic insufficiency. On the use of the inhaler instructions. The patient must be taught how to use the inhaler, and to periodically check the inhalation technique. Before the first use of the inhaler and after 3 days or more after the break in his use of the first dose should be sprayed in the air to make sure it works.

 

  1. Take the inhaler between thumb and forefinger, as shown in the figure.
  2. Remove the protective cap from the inhaler mouthpiece.
  3. Take the mouthpiece into your mouth, tightly clasping his lips, and fully exhale through the nose.
  4. Make a long deep breath and simultaneously performed by pressing on the end of the balloon forefinger.
  5. After inhalation as long as you can hold your breath. Then remove the mouthpiece from the mouth and continue to breathe normally.
  6. For the second dose, holding the inhaler in a vertical position, wait 30 seconds and then repeat steps 3 through 5.
    After use, the mouthpiece is closed tight protective cap.
    Caution! Follow steps 3 and 4, you can not rush. It should begin to breathe in as slowly as possible just before pressing the inhaler valve.
    If the gas is partially out of the top of the inhaler or from the corners of the patient’s mouth, you should repeat tren acetate half life the procedure from step 3.
    For patients with weak hands easier to hold the inhaler with both hands. Therefore, the upper part of the inhaler should hold two index fingers and its lower part – thumbs.
    After inhalation, it is recommended to rinse the mouth with water.
    Recommended to wash it with warm water as contamination In order to maintain the purity of the mouthpiece.
    No clinical data on the use of Foster with a spacer; therefore recommended dosage formulation given considering that the inhaler is used without a spacer with a standard activator.
    It will be appreciated that when using Foster a spacer may be necessary to dose adjustment.Side effects
    Foster contains beclometasone dipropionate and formoterol fumarate, and therefore it is expected that it can cause side effects that are typical of these components. There tren acetate half life is no evidence that their simultaneous application causes additional side effects.
    Side effects associated with the use of formoterol and beclomethasone dipropionate in a fixed combination (Foster) are shown below.

tren steroid side effects

The conjugates of glucuronic acid is not active. The second important pathway formoterol  by conjugation at two phenolic hydroxyl groups. Cytochrome  enzymes, tren steroid side effects is involved in the formoterol. There is reason to assume that formoterol metabolism is carried out mainly in the liver. Formoterol does not inhibit enzymes at therapeutically relevant concentrations.

Excretion Total formoterol renal excretion following inhalation of a single dose via metered dry powder inhaler increases linearly in the dose range 12-96 mg. Indicators and excretion of unchanged total formoterol, on average, are 8 and 25%, respectively. Based on the measurement of plasma concentrations of formoterol after single inhalation of a dose of 120 mg in 12 healthy volunteers was designated , which was 10 hours. The ratio  enantiomers of unchanged drug in renal excretion is respectively 40 and 60%. The relative ratio of these two parameters is not changed within the range of dosages investigated; . no evidence of accumulation of one enantiomer relative to the other after receiving repeated doses in healthy volunteers after oral administration (40-80 mg), 6.10% of the dose was found in the urine as unchanged drug; 8% of the dose was present in the form of glucuronides. Total 67% of the oral tren steroid side effects dose excreted by the kidneys formoterol (mainly as metabolites), the remainder of the dose – via the intestine. Renal clearance of formoterol is 150 ml / min.

Indications
Basic therapy of asthma, providing for the appointment of combination therapy (inhaled corticosteroids and β2-adrenomimetic long-acting):
Patients with symptoms that are inadequately controlled with inhaled corticosteroids and β2-agonists short action;
Patients on effective maintenance doses of inhaled corticosteroids and β2-agonists long-acting.

Contraindications
: Hypersensitivity to the drug, children under 12 years.

Precautions
Pregnancy, lactation, pulmonary tuberculosis, fungal, viral or bacterial infections of the respiratory system, thyrotoxicosis, pheochromocytoma, diabetes, uncontrolled hypokalemia, idiopa-matic hypertrophic subaortic stenosis, atrioventricular block III degree, severe hypertension, aneurysm of any location or other severe cardiovascular disease (acute myocardial infarction, ischemic heart disease, tachyarrhythmia, tren steroid side effects for chronic heart failure, the extended .

Pregnancy and lactation
No clinical data on the use of Foster during pregnancy. In animal studies embryotoxic or teratogenic effects vyyaleno was not.
During pregnancy, tren steroid side effects should be used only in cases where the benefit of the drug outweighs the potential risk to the fetus. It is recommended to prescribe the lowest dose that provides effective control of asthma symptoms.
There is no data on the penetration of Foster in the breast milk of women. Foster can be administered in lactating women only when the expected therapeutic effect for the mother outweighs the potential risk to the child.