Among the most common side effects associated with taking formoterol are described such typical for beta2-agonists, such as: hypokalaemia, headache, tremor, palpitations, cough, muscle cramps, lengthening the tren hexahydrobenzylcarbonate. Side effects that are typical of beclomethasone dipropionate: candidiasis of the mucous membranes of the mouth and throat, throat irritation.
As with other inhaled medications, Foster may cause paradoxical bronchospasm.
Other side effects that are typical of formoterol: platelet-topeniya, angioneurotic edema, hyperglycemia, increased the blood levels of insulin, free fatty acids, glycerol and ketone derivatives, sleep disturbances, hallucinations, fatigue, anxiety, change in taste (dysgeusia), tachycardia, tachyarrhythmia, ventricular arrythmia, angina pectoris (ischemic heart disease), atrial fibrillation, hypertension, hypotension, worsening of asthma, shortness of breath, nausea, itching, skin rash, urticaria, rash, myalgia, nephritis, peripheral edema.
Systemic effects of corticosteroids (including beclomethasone dipropionate) occur at high doses for a long time. These include: inhibition of adrenal function, decreased bone mineral density, growth retardation in children and adolescents, cataract and glaucoma. Hypersensitivity reactions include itching, rash, erythema and edema of the eyes, face, lips and throat.
In case of overdose appear typical for tren hexahydrobenzylcarbonate symptoms associated with formoterol, such as nausea, vomiting, headache, tremor, drowsiness, palpitations, tachycardia, ventricular arrhythmias, prolongation of the QTc-interval, metabolic acidosis, hypokalemia, hyperglycemia.
If you have symptoms overdose shown symptomatic treatment. In severe cases, hospitalization. It may be considered the use of cardioselective beta-blockers in compliance with caution, since the use of these funds can cause bronchospasm. It is necessary to monitoring the level of potassium in the blood plasma.
Inhalation doses of beclomethasone dipropionate recommended above can cause temporary suppression of adrenocortical function. It does not usually require the adoption of any emergency measures, since in most cases normal adrenal function is recovered in a few days. . It is recommended to control the level of cortisol in the blood plasma
in chronic receiving excessive doses of beclomethasone dipropionate may manifest its systemic effect: it may be a significant inhibition of adrenal cortex up to adrenal crisis. Acute adrenal crisis manifested hypoglycemia accompanied by confusion and / or convulsions. Situations that can serve as a triggering factor of acute adrenal crisis, include trauma, surgery, infection or rapid dose reduction is part of the Foster beclomethasone. In chronic overdose recommended control reserve of adrenocortical function.
Interaction with other drugs
blockers β-adrenergic receptors may attenuate the effect of formoterol. Foster should not be administered simultaneously with tren hexahydrobenzylcarbonate (including eye drops) unless required cases.
In a joint reception Foster and other β-adrenergic drugs may increase formoterol side effects.
Co-administration of Foster and quinidine, disopyramide, procainamide, phenothiazines, antihistamines medicines (terfenadine), monoamine oxidase inhibitors and tricyclic antidepressants can prolong the QTc – interval and increase the risk of ventricular arrhythmias.
in addition, levodopa, levothyroxine, oxytocin and alcohol can reduce the tolerance of the heart muscle to agonists.
Co-administration of inhibitors, and drugs with similar properties such as furazolidone and procarbazine, may cause increased blood pressure. There is an increased risk of arrhythmias in patients receiving general anesthesia, halogenated hydrocarbons drugs.
As a result, the use may occur hypokalemia, which may be exacerbated by the concomitant treatment of xanthine derivatives, mineral derivatives of corticosteroids or diuretics. Hypokalemia may enhance susceptibility to the development of arrhythmias in patients receiving cardiac glycosides.
Due to the content of a small amount of ethanol may be a manifestation of interaction in patients with hypersensitivity taking disulfiram or metronidazole.
If patients have these co-morbidities, as coronary heart disease, myocardial infarction, exacerbation of hypertension, cardiac arrhythmias, congestive heart failure, diabetes, prostatic hypertrophy, glaucoma, you must take extra care when choosing .
It precautions in the treatment of patients with prolonged . Acceptance of formoterol may cause lengthening of tren hexahydrobenzylcarbonate Foster can only be used in patients with tachyarrhythmia, subject to special precautions, such as monitoring.
It should take special precautions in patients with unstable asthma patients treated with bronchodilators short action for relief of attacks during exacerbation of severe asthma, because the risk of hypokalemia increases against the background of hypoxia and in other conditions when the increased probability of developing gipokaliemicheskogo effect. In such cases it is advisable to control the content of potassium in serum.
Inhaled formoterol high tren hexahydrobenzylcarbonate doses can lead to an increase in blood sugar levels. The treatment should monitor the concentration of blood glucose in patients with diabetes.