Patients should take extra calcium and of side effects of trenbolone, if intake of food is insufficient. Use in elderly: clinical trials was not observed differences in efficacy or safety profiles of alendronate depending on age. Therefore, dose adjustment in elderly patients is not required.
Use in renal impairment: dose adjustment for patients with glomerular filtration rate greater than 35 ml / min is needed. Alendronate is not recommended for patients with kidney failure, where of less than 35 ml / min, due to lack of data on the application. Study of the drug side effects of trenbolone once pedal action in the treatment of osteoporosis, glucocorticoid induced osteoporosis, have been conducted.
In two three-year studies of almost identical design, with in postmenopausal women safety profiles of alendronate 10 mg / day and placebo were generally similar. Adverse events described in these studies as a possibly, probably, or definitely related to the drug taking , presented in the table below. Adverse events occurred in ≥ 1% of patients in each group receive parabolin side effects in the annual study. In ≥ 1% of patients taking alendropat 10 mg / day, adverse events were observed more frequently than with placebo in three-year study.
When possible overdose hypocalcemia, hypophosphatemia, adverse events from the upper gastrointestinal tract, including stomach upset, heartburn, esophagitis, gastritis, ulcers of the stomach and esophagus. Specific treatment alendronate no overdose. The patient tren side effects should take milk or antacids to bind alendronate. To avoid irritation of the esophagus should not induce vomiting. Patients should maintain an upright position.
Interaction with other drugs
The absorption of alendronate may be violated if the drug is taken simultaneously with the poor, drinks (including mineral water), calcium preparations, antacids and other drugs for oral administration. In this regard, the interval between doses of the drug side effects of trenboloneand other medicines taken by mouth should be at least 30 minutes.
Other clinically significant interactions with drugs is expected. In clinical studies, some patients received estrogen (intravaginal, tranedermalyyu or orally), taking alendronate. Adverse events associated with their simultaneous application, has not been revealed.
As the use of non-steroidal anti-inflammatory is associated with the development of erosive and ulcerative lesions of the gastrointestinal tract, care should be taken while the application of and alendronate.
Although specific interaction studies have not been conducted, in clinical studies alendronate was used in conjunction with a wide range of commonly prescribed drugs without evidence side effects of trenbolone of clinical adverse interactions.