The conjugates of glucuronic acid is not active. The second important pathway formoterol by conjugation at two phenolic hydroxyl groups. Cytochrome enzymes, tren steroid side effects is involved in the formoterol. There is reason to assume that formoterol metabolism is carried out mainly in the liver. Formoterol does not inhibit enzymes at therapeutically relevant concentrations.
Excretion Total formoterol renal excretion following inhalation of a single dose via metered dry powder inhaler increases linearly in the dose range 12-96 mg. Indicators and excretion of unchanged total formoterol, on average, are 8 and 25%, respectively. Based on the measurement of plasma concentrations of formoterol after single inhalation of a dose of 120 mg in 12 healthy volunteers was designated , which was 10 hours. The ratio enantiomers of unchanged drug in renal excretion is respectively 40 and 60%. The relative ratio of these two parameters is not changed within the range of dosages investigated; . no evidence of accumulation of one enantiomer relative to the other after receiving repeated doses in healthy volunteers after oral administration (40-80 mg), 6.10% of the dose was found in the urine as unchanged drug; 8% of the dose was present in the form of glucuronides. Total 67% of the oral tren steroid side effects dose excreted by the kidneys formoterol (mainly as metabolites), the remainder of the dose – via the intestine. Renal clearance of formoterol is 150 ml / min.
Basic therapy of asthma, providing for the appointment of combination therapy (inhaled corticosteroids and β2-adrenomimetic long-acting):
Patients with symptoms that are inadequately controlled with inhaled corticosteroids and β2-agonists short action;
Patients on effective maintenance doses of inhaled corticosteroids and β2-agonists long-acting.
: Hypersensitivity to the drug, children under 12 years.
Pregnancy, lactation, pulmonary tuberculosis, fungal, viral or bacterial infections of the respiratory system, thyrotoxicosis, pheochromocytoma, diabetes, uncontrolled hypokalemia, idiopa-matic hypertrophic subaortic stenosis, atrioventricular block III degree, severe hypertension, aneurysm of any location or other severe cardiovascular disease (acute myocardial infarction, ischemic heart disease, tachyarrhythmia, tren steroid side effects for chronic heart failure, the extended .
Pregnancy and lactation
No clinical data on the use of Foster during pregnancy. In animal studies embryotoxic or teratogenic effects vyyaleno was not.
During pregnancy, tren steroid side effects should be used only in cases where the benefit of the drug outweighs the potential risk to the fetus. It is recommended to prescribe the lowest dose that provides effective control of asthma symptoms.
There is no data on the penetration of Foster in the breast milk of women. Foster can be administered in lactating women only when the expected therapeutic effect for the mother outweighs the potential risk to the child.